ABSTRACT
Objective:Comparative analysis of total parathyroidectomy (total parathyroidectomy, TPTX) and total parathyroidectomy with autoransplantation (total parathyroidectomy with autoransplantation, TPTX+ AT) for the treatment of uremia secondary hyperparathyroidism Clinical efficacy.Methods:A total of 82 cases of SHPT treated with TPTX or TPTX + AT in First Affiliated Hospital of Chengdu Medical College from June 2015 to July 2019 were collected According to the operation methods, 82 cases were devided into TPTX group and TPTX+ AT group.There were 34 patients in the TPTX group, 17 males and 17 females, with an average age of (45.97±8.96) years, and 48 patients in the TPTX+ AT group, 21 males and 27 females, with an average age of (49.12±7.30) years. SPSS 20.0 software was used for statistical analysis. The measurement data conforming to normal distribution were represented by ( Mean± SD), and the comparison between groups was performed by t test. The data not conforming to normal distribution were represented by quaternary M( P25, P75), and the comparison between groups was performed by non-parametric test. Enumeration data were expressed as cases (%), and comparison was performed by χ2 test. The postoperative complications, postoperative efficacy and recurrence rate were compared between the two procedures. Results:Both TPTX and TPTX+ AT had a low incidence of complications after SHPT, and both of them could effectively relieve symptoms such as bone pain, skin itching and subcutaneous soft tissue calcification.After 1 year of follow-up, both of the two surgical methods can effectively reduce blood calcium (TPTX group: t= 14.522, P<0.05; TPTX+ AT group: t=13.704, P<0.05), blood phosphorus (TPTX group: t=35.022, P<0.05; TPTX+ AT group: t=42.303, P<0.05) and iPTH(TPTX group: t= 20.166, P<0.05; TPTX+ AT group: t= 23.976, P<0.05), but the reduction of iPTH in TPTX group was more effective than that in TPTX+ AT group ( t=-3.416, P<0.05). Conclusion:Both TPTX and TPTX+ AT can effectively treat SHPT, and have high safety and can be used as an alternative for SHPT treatment.
ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical effects differences and partial mechanism for chronic nonbacterial prostatitis (CNP) among drug oil moxibustion, simple moxibustion, and conventional western medicine.</p><p><b>METHODS</b>A total of 120 patients who met the criteria of inclusion were randomly assigned into a drug oil moxibustion group, a moxibustion group and a western medication group, 40 cases in each one. Moxibustion was used at Guanyuan (CV 4), Zhongji (CV 3), Qihai (CV 6) and bilateral Yinlingquan (SP 9), Sanyinjiao (SP 6), Shenshu (BL 23), Mingmen (GV 4), Pangguangshu (BL 28), Ciliao (BL 32), and Zhibian (BL 54), etc. The same moxibustion was used at the same acupoints in the drug oil moxibustion group after external application of medicated oil. Thirty min treatment was used once a day in alternated abdomen and back. In the western medication group, oral tamsulosin hydrochloride capsules were applied once a day, one capsule at a time. All the treatment was given for 30 days. Chronic prostatitis symptom index from National Institutes for Health (NIH-CPSI), the contents of Zinc (Zn) and C-reactive protein (CRP), as well as the number of white blood cells (WBC) and density of lecithin bodies were observed before and after treatment and 1 month after treatment. The effects were evaluated after treatment.</p><p><b>RESULTS</b>After treatment, the total effective rate of the drug oil moxibustion group was 90.0% (36/40), which was significantly higher than 72.5% (29/40) of the moxibustion group and 62.5% (25/40) of the western medication group (both<0.05). After treatment and at follow-up in the three groups, the NIH-CPSI scores were lower than those before treatment (all<0.05), and those in the drug oil moxibustion group were lower than the results in the moxibustion group and the western medication group (all<0.05). The contents of Zn in the three groups were higher than those before treatment (all<0.05), with better results in the drug oil moxibustion group (all<0.05), and higher Zn contents in the moxibustion group compared with those in the western medication group (both<0.05). The CRP levels were lower than those before treatment (all<0.05), and those in the drug oil moxibustion group were better than those in the moxibustion group and western medication group (all<0.05). The CRP contents in the moxibustion group were lower than those in the western medication group (both<0.05). The number of WBC were lower than those before treatment (all<0.05), with better results in the drug oil moxibustion group (all<0.05). The concentrations of lecithin were higher than those before treatment (all<0.05), with better results in the drug oil moxibustion group (all<0.05).</p><p><b>CONCLUSIONS</b>The clinical effect of drug oil moxibustion is better than those of simple moxibustion and western medicine, which has advantages in improving clinical symptoms, Zn, the density of lecithin body and decreasing CRP content and the number of WBC.</p>